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![]() Posted: Post subject: Have you been genetically tested? |
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I was diagnosed at the age of 30 of having Klinefelter's Syndrome Karotype Variant 49 XX / XXY when I started developing breasts, I have had two breast reduction surgeries and yet they are coming back. And upon further examination thru CAT Scans and MRI's the medical staff of John's Hopkins discovered I also had an under-developed ovary and female plumbing inside that was entwined with the male organs. Back in the day you didn't talk about these things with your parents as it was unheard of, but after sometime I felt the need to hide the fact of it all because of personal shame and the mental abuse one endures in school from teasing and hazing, especially during P.E. . Some people for lack of better words called me a hermaphrodite. I present myself as a man and have the same plumbing as a male, a manly face and deep baritone voice and I try my hardest to not show anymore traits than I have to. I see people here posting they want someone that is healthy and free of ------ disease, in essence I am healthy and I definitely do not have a ------ disease, but I do have a genetic problem. Klinefelter syndrome is a genetic disorder that occurs in males who have three or more --- chromosomes. At least two of the chromosomes must be X chromosomes, and one must be a Y chromosome. The condition causes males to have some female-like physical features.
Klinefelter syndrome is caused when a fertilized egg has an extra --- chromosome. Most people have 46 chromosomes in the nucleus of each cell of their bodies. These chromosomes exist in matched pairs, meaning there are 23 pairs. One of these 23 pairs determines whether a person will be a male or a female. This pair is called the --- chromosome pair. The --- chromosomes are designated by letters. The letter X designates the chromosome associated with being female. The letter Y designates the chromosome associated with being male. Most females have two X chromosomes. Most males have an X chromosome and a Y chromosome. If two X chromosomes are present, and there is also a Y chromosome, the person will be a male with the Klinefelter syndrome. This condition is also called 47,XXY. Some people with Klinefelter syndrome have more two X chromosomes and more than one Y chromosome.
The physical features of Klinefelter syndrome are caused by abnormally low production of the male --- hormones.
There are 23 pairs of chromosomes found in each cell of the body, and each contain genes that determine our coloring, our features, and our ---. Women inherit two X chromosomes -- one from each parent, written 46,XX. Men inherit an X chromosome from their mothers and a Y chromosome from their fathers, written 46,XY. Some individuals, however, have an additional X chromosome in their chromosomal arrangement, referred to as 47,XXY, or more commonly, just XXY. The cause is unknown, yet XXY occurs in approximately 1 in every 500 to 1000 live male births, making it one of the most common chromosome variations. The XXY variation is identified in an individual through a karyotype, a buccal smear, or FISH.
In 1942, Dr. Harry Klinefelter while working at the Massachusetts General Hospital in Boston published with fellow researchers a report about nine individuals who had similar features:
tall (around six feet)
small testes or hypogonadism
inability to produce sperm
sparse facial and body hair
gynecomastia
By the late 1950's researchers discovered that those with these features (Klinefelter syndrome), had an extra X --- chromosome, and were XXY instead of the typical male arrangement of XY. Subsequent research studies expanded and revised the original features to include the following as possible associated conditions:
infertility
incomplete masculinization; feminine, or pear shaped, body and body hair distribution
decreased libido
altered brain structure
osteoporosis
taurodontism
venous disease
autoimmune disorders such as lupus
low energy
low self esteem
communication difficulties, especially with expressive language
frustration-based outbursts
motor skill issues
developmental delays
Other conditions that can be confused with Klinefelter syndrome.Some researchers list all of these as being Klinefelter syndrome. However, there is a trend among modern practitioners to distinguish chromosomal variations from any possible resulting syndromes, diseases, and conditions.
It is important to remember that not all XXYs will develop any or all of these conditions. Since your extra X is just one out of 47, you have a lot of other genetic material that affects you in a variety of ways, and the extra X can differ in genetic coding from individual to individual.
Life expectantcy of someone with Klinefelter Syndrome is that of 30 years old as most die from cancer or even by suicide. And suicide is not an option here.... |
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![]() Posted: Post subject: mixed gender traits |
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I have not been diagnosed with Klinefelters Syndrome. However, I was born with some of the features as someone who has been; hypogonadism, minimal ability to grow facial and body hair, infertility, and gynomastia. My parents never discussed my physical abnormality with me. All the same, as a child I somehow realized my difference from other boys. I didn't fit in anywhere. I can't say I felt like a girl, likely due to the confusion between my apparent gender and the gender-oddness I felt. Only as I matured and formed some language around what was different about me. I began to identify myself more and more as female.
School, of course, was hellish. Adoloscents are quick to single out differnences and punish those who stand out in any way. By that time I was fully aware of my physical anomolies but felt in no position to do anything about them. I was not born to approachable parents.
As a young adult I did my best to persevere in the male role I thought was expected of me. Over time I became depressed and despondent. I had no self esteem and was living carefully to avoid exposing anything I thought may be seen as feminine behaviours. To make matters more difficult I found myself far more attracted to men than to women. By my late twenties I was experimenting -------- as well as experimenting with femininity.
In my thirties, by then already living part-time as a woman, I made a startling discovery regarding my birth, almost by accident. I had begun to take an astrology class. To accurately compose a natal chart I needed to know the time of my birth. My mother couldn't remember. As I was living very near the hospital where I was born, I made a visit there to the statistics department. When the clerk looked for me in the birth ledger, there beside my male name was a female --- designation, with a question mark beside it. In those days, my condition was recorded as "ambiguous sex". I had been born with a little of each sexes external genitalia but neither male nor female internal reproductive gonads.
In my mid thirties I sought and received surgical reassignment and now live completely as a woman. As part of the diagnostic procedure, a psychiatrist with an interest in intersexed individuals requested a chromosome karotyping test. Nothing unusual presented. Despite my ambiguos gender traits, and self-conviction of femininity, I am chromosomally male.
Danielle
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